pentobarbital will reduce the extent or influence of isavuconazonium sulfate by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
Reserve concomitant prescribing of these drugs in people for whom other treatment method options are insufficient. Limit dosages and durations to your minimum required. Monitor closely for signs of respiratory depression and sedation.
pentobarbital will lessen the level or effect of tinidazole by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
pentobarbital will reduce the extent or effect of etravirine by impacting hepatic enzyme CYP2C9/ten metabolism. Use Warning/Watch.
pentobarbital will lower the level or impact of bosentan by influencing hepatic enzyme CYP2C9/10 metabolism. Minimal/Significance Unidentified.
pentobarbital will decrease the extent or outcome of dasatinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
Observe Closely (one)pentobarbital will reduce the level or outcome of tadalafil by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will minimize the level or influence of etoposide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
Contraindicated (1)pentobarbital will decrease the level or result of cobimetinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Prevent coadministration. Potent or average CYP3A inducers may possibly lower cobimetinib systemic publicity by >eighty% and lessen its efficacy.
pentobarbital will lessen the extent or influence get more info of solifenacin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
Contraindicated. Coadministration of lorlatinib with solid CYP3A inducers is contraindicated. Discontinue the robust CYP3A inducer for 3 plasma 50 percent-lives right before initiating lorlatinib.
Observe Closely (three)pentobarbital will decrease the level or effect of diazepam intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Solid or average CYP3A4 inducers may improve price of diazepam elimination; as a result, efficacy of diazepam could be lowered.
pentobarbital will lower the extent or effect of cannabidiol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Intently. Consider a rise in cannabidiol dosage (dependant on scientific reaction and tolerability) when coadministered with a solid CYP3A4 inducer.
pentobarbital raises toxicity of methoxyflurane by increasing metabolism. Contraindicated. Greater metabolism of methoxyflurane to nephrotoxic compounds.